Grant was NHSGGC for chief executive and has worked for the NHS for over 40 years.
She joined the NHS in 1983 as a management services officer within Highland Health Board and progressed through a variety of management posts in Lanarkshire and Glasgow before being appointed to her first chief executive role with NHS Forth Valley in October 2013. She returned to NHS Greater Glasgow and Clyde in 2017 as chief executive.
Grant said: ‘I have decided to retire after 41 years' service to NHS Scotland. Within that time, I have been fortunate to work in five health boards across Scotland. I have had the privilege of working with many outstanding colleagues but I believe the time is right to hand over the reins to a new chief executive.'
Dr Lesley Thomson KC, chair, NHS Greater Glasgow and Clyde, said: ‘Jane has been a tremendous chief executive, working tirelessly for patients and steering the organisation to deliver the best possible healthcare for the local population.
‘On a personal level, she has provided immense support to me in the months since I took up post and I am very grateful for her support. On behalf of the board, I thank Jane for her service to NHS Greater Glasgow and Clyde.'
Grant will remain in post until the end of the year.